Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
Identifieur interne : 001B25 ( Main/Exploration ); précédent : 001B24; suivant : 001B26Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
Auteurs : Vineet D. Menachery ; Amie J. Eisfeld ; Alexandra Sch Fer ; Laurence Josset ; Amy C. Sims ; Sean Proll ; Shufang Fan ; Chengjun Li ; Gabriele Neumann ; Susan C. Tilton ; Jean Chang ; Lisa E. Gralinski ; Casey Long ; Richard Green ; Christopher M. Williams ; Jeffrey Weiss ; Melissa M. Matzke ; Bobbie-Jo Webb-Robertson ; Athena A. Schepmoes ; Anil K. Shukla ; Thomas O. Metz ; Richard D. Smith ; Katrina M. Waters ; Michael G. Katze ; Yoshihiro Kawaoka [États-Unis] ; Ralph S. BaricSource :
- mBio [ 2150-7511 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Analyse de regroupements, Animaux, Coronavirus (physiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Facteurs de transcription (métabolisme), Grippe humaine (génétique), Grippe humaine (métabolisme), Grippe humaine (virologie), Histone (métabolisme), Humains, Infections à coronavirus (génétique), Infections à coronavirus (métabolisme), Infections à coronavirus (virologie), Interactions hôte-pathogène (génétique), Interféron de type I, Interférons (métabolisme), Interférons (pharmacologie), Liaison aux protéines, Lignée cellulaire, Modèles biologiques, Protéines virales non structurales (métabolisme), Protéomique, Régulation de l'expression des gènes (), Sous-type H5N1 du virus de la grippe A (physiologie), Virus de la grippe A (physiologie), Virus du SRAS (physiologie).
- MESH :
- génétique : Grippe humaine, Infections à coronavirus, Interactions hôte-pathogène.
- métabolisme : Facteurs de transcription, Grippe humaine, Histone, Infections à coronavirus, Interférons, Protéines virales non structurales.
- pharmacologie : Interférons.
- physiologie : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient, Sous-type H5N1 du virus de la grippe A, Virus de la grippe A, Virus du SRAS.
- virologie : Grippe humaine, Infections à coronavirus.
- Analyse de profil d'expression de gènes, Analyse de regroupements, Animaux, Humains, Interféron de type I, Liaison aux protéines, Lignée cellulaire, Modèles biologiques, Protéomique, Régulation de l'expression des gènes.
English descriptors
- KwdEn :
- Animals, Cell Line, Cluster Analysis, Coronavirus (physiology), Coronavirus Infections (genetics), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Gene Expression Profiling, Gene Expression Regulation (drug effects), Histones (metabolism), Host-Pathogen Interactions (genetics), Humans, Influenza A Virus, H5N1 Subtype (physiology), Influenza A virus (physiology), Influenza, Human (genetics), Influenza, Human (metabolism), Influenza, Human (virology), Interferon Type I, Interferons (metabolism), Interferons (pharmacology), Middle East Respiratory Syndrome Coronavirus (physiology), Models, Biological, Protein Binding, Proteomics, SARS Virus (physiology), Transcription Factors (metabolism), Viral Nonstructural Proteins (metabolism).
- MESH :
- chemical , metabolism : Histones, Interferons, Transcription Factors, Viral Nonstructural Proteins.
- drug effects : Gene Expression Regulation.
- genetics : Coronavirus Infections, Host-Pathogen Interactions, Influenza, Human.
- metabolism : Coronavirus Infections, Influenza, Human.
- chemical , pharmacology : Interferons.
- physiology : Coronavirus, Influenza A Virus, H5N1 Subtype, Influenza A virus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Influenza, Human.
- Animals, Cell Line, Cluster Analysis, Gene Expression Profiling, Humans, Interferon Type I, Models, Biological, Protein Binding, Proteomics.
Abstract
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.
Url:
DOI: 10.1128/mBio.01174-14
PubMed: 24846384
PubMed Central: 4030454
Affiliations:
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Le document en format XML
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Menachery</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J." last="Eisfeld">Amie J. Eisfeld</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Josset, Laurence" sort="Josset, Laurence" uniqKey="Josset L" first="Laurence" last="Josset">Laurence Josset</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Proll, Sean" sort="Proll, Sean" uniqKey="Proll S" first="Sean" last="Proll">Sean Proll</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Fan, Shufang" sort="Fan, Shufang" uniqKey="Fan S" first="Shufang" last="Fan">Shufang Fan</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Neumann, Gabriele" sort="Neumann, Gabriele" uniqKey="Neumann G" first="Gabriele" last="Neumann">Gabriele Neumann</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Tilton, Susan C" sort="Tilton, Susan C" uniqKey="Tilton S" first="Susan C." last="Tilton">Susan C. Tilton</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E." last="Gralinski">Lisa E. Gralinski</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Long, Casey" sort="Long, Casey" uniqKey="Long C" first="Casey" last="Long">Casey Long</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Green, Richard" sort="Green, Richard" uniqKey="Green R" first="Richard" last="Green">Richard Green</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Williams, Christopher M" sort="Williams, Christopher M" uniqKey="Williams C" first="Christopher M." last="Williams">Christopher M. Williams</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Weiss, Jeffrey" sort="Weiss, Jeffrey" uniqKey="Weiss J" first="Jeffrey" last="Weiss">Jeffrey Weiss</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Matzke, Melissa M" sort="Matzke, Melissa M" uniqKey="Matzke M" first="Melissa M." last="Matzke">Melissa M. Matzke</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Webb Robertson, Bobbie Jo" sort="Webb Robertson, Bobbie Jo" uniqKey="Webb Robertson B" first="Bobbie-Jo" last="Webb-Robertson">Bobbie-Jo Webb-Robertson</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Schepmoes, Athena A" sort="Schepmoes, Athena A" uniqKey="Schepmoes A" first="Athena A." last="Schepmoes">Athena A. Schepmoes</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Shukla, Anil K" sort="Shukla, Anil K" uniqKey="Shukla A" first="Anil K." last="Shukla">Anil K. Shukla</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O." last="Metz">Thomas O. Metz</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D." last="Smith">Richard D. Smith</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M." last="Waters">Katrina M. Waters</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G." last="Katze">Michael G. Katze</name></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cluster Analysis</term><term>Coronavirus (physiology)</term><term>Coronavirus Infections (genetics)</term><term>Coronavirus Infections (metabolism)</term><term>Coronavirus Infections (virology)</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation (drug effects)</term><term>Histones (metabolism)</term><term>Host-Pathogen Interactions (genetics)</term><term>Humans</term><term>Influenza A Virus, H5N1 Subtype (physiology)</term><term>Influenza A virus (physiology)</term><term>Influenza, Human (genetics)</term><term>Influenza, Human (metabolism)</term><term>Influenza, Human (virology)</term><term>Interferon Type I</term><term>Interferons (metabolism)</term><term>Interferons (pharmacology)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Models, Biological</term><term>Protein Binding</term><term>Proteomics</term><term>SARS Virus (physiology)</term><term>Transcription Factors (metabolism)</term><term>Viral Nonstructural Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Analyse de regroupements</term><term>Animaux</term><term>Coronavirus (physiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Facteurs de transcription (métabolisme)</term><term>Grippe humaine (génétique)</term><term>Grippe humaine (métabolisme)</term><term>Grippe humaine (virologie)</term><term>Histone (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (génétique)</term><term>Infections à coronavirus (métabolisme)</term><term>Infections à coronavirus (virologie)</term><term>Interactions hôte-pathogène (génétique)</term><term>Interféron de type I</term><term>Interférons (métabolisme)</term><term>Interférons (pharmacologie)</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles biologiques</term><term>Protéines virales non structurales (métabolisme)</term><term>Protéomique</term><term>Régulation de l'expression des gènes ()</term><term>Sous-type H5N1 du virus de la grippe A (physiologie)</term><term>Virus de la grippe A (physiologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Histones</term><term>Interferons</term><term>Transcription Factors</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term><term>Host-Pathogen Interactions</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Grippe humaine</term><term>Infections à coronavirus</term><term>Interactions hôte-pathogène</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus Infections</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term><term>Grippe humaine</term><term>Histone</term><term>Infections à coronavirus</term><term>Interférons</term><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Interférons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interferons</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Virus de la grippe A</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A virus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cluster Analysis</term><term>Gene Expression Profiling</term><term>Humans</term><term>Interferon Type I</term><term>Models, Biological</term><term>Protein Binding</term><term>Proteomics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Analyse de regroupements</term><term>Animaux</term><term>Humains</term><term>Interféron de type I</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles biologiques</term><term>Protéomique</term><term>Régulation de l'expression des gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillim Ross, L" uniqKey="Gillim Ross L">L Gillim-Ross</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name 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Baric</name><name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J." last="Eisfeld">Amie J. Eisfeld</name><name sortKey="Fan, Shufang" sort="Fan, Shufang" uniqKey="Fan S" first="Shufang" last="Fan">Shufang Fan</name><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E." last="Gralinski">Lisa E. Gralinski</name><name sortKey="Green, Richard" sort="Green, Richard" uniqKey="Green R" first="Richard" last="Green">Richard Green</name><name sortKey="Josset, Laurence" sort="Josset, Laurence" uniqKey="Josset L" first="Laurence" last="Josset">Laurence Josset</name><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G." last="Katze">Michael G. Katze</name><name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name><name sortKey="Long, Casey" sort="Long, Casey" uniqKey="Long C" first="Casey" last="Long">Casey Long</name><name sortKey="Matzke, Melissa M" sort="Matzke, Melissa M" uniqKey="Matzke M" first="Melissa M." last="Matzke">Melissa M. Matzke</name><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O." last="Metz">Thomas O. Metz</name><name sortKey="Neumann, Gabriele" sort="Neumann, Gabriele" uniqKey="Neumann G" first="Gabriele" last="Neumann">Gabriele Neumann</name><name sortKey="Proll, Sean" sort="Proll, Sean" uniqKey="Proll S" first="Sean" last="Proll">Sean Proll</name><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name><name sortKey="Schepmoes, Athena A" sort="Schepmoes, Athena A" uniqKey="Schepmoes A" first="Athena A." last="Schepmoes">Athena A. Schepmoes</name><name sortKey="Shukla, Anil K" sort="Shukla, Anil K" uniqKey="Shukla A" first="Anil K." last="Shukla">Anil K. Shukla</name><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D." last="Smith">Richard D. Smith</name><name sortKey="Tilton, Susan C" sort="Tilton, Susan C" uniqKey="Tilton S" first="Susan C." last="Tilton">Susan C. Tilton</name><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M." last="Waters">Katrina M. Waters</name><name sortKey="Webb Robertson, Bobbie Jo" sort="Webb Robertson, Bobbie Jo" uniqKey="Webb Robertson B" first="Bobbie-Jo" last="Webb-Robertson">Bobbie-Jo Webb-Robertson</name><name sortKey="Weiss, Jeffrey" sort="Weiss, Jeffrey" uniqKey="Weiss J" first="Jeffrey" last="Weiss">Jeffrey Weiss</name><name sortKey="Williams, Christopher M" sort="Williams, Christopher M" uniqKey="Williams C" first="Christopher M." last="Williams">Christopher M. Williams</name></noCountry><country name="États-Unis"><region name="Wisconsin"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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